In this episode we discuss: Whether Berberine and Urolithin A are good options for weight loss How Berberine lowers your blood sugar and whether this is really a good thing The effects of Berberine and Urolithin A on your gut Whether you always need to avoid blood sugar spikes Whether you always need to have protein with your carbohydrates Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-122-weight-loss-with-berberine-and-urolithin-a-blood-sugar-spikes-and-pairing-protein-with-carbs-qa/ Timestamps: 0:00 – intro 1:10 – what are berberine and urolithin A? 2:26 – the benefits of berberine on gut health 9:06 – berberine as a mitochondrial poison and the mechanisms of berberine’s toxicity and blood-sugar-lowering effects 13:13 – of the effects urolithin A on mitochondria and the gut 18:15 – whether urolithin A is beneficial for weight loss and increases brown adipose tissue activity 22:13 – the importance of avoiding reductionistic thinking around supplements touted for weight loss benefits 26:31 – powerful weight loss strategies that are simple and effective, without supplementation 31:02 – whether we always need to avoid blood sugar spikes and dips 35:30 – when having protein alongside carbs is necessary and why increasing carbohydrate intake improves insulin sensitivity, even in people with type 2 diabetes 40:49 – how fat, fiber, and protein help slow the absorption of carbohydrates and improve blood sugar management 46:20 – issues with grain-based carbs and the importance of finding carb sources that work for you

In this episode we discuss: How to fix adrenal fatigue and adrenal insufficiency and whether these are really adrenal problems Whether it makes sense to use desiccated adrenal products or hydrocortisone for adrenal fatigue How the GAPS diet can resolve autoimmune issues and whether you should consider trying it How to improve fat digestion and bile flow How to improve digestion without a gallbladder Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-121-how-to-address-adrenal-fatigue-gaps-diet-concerns-and-gallbladder-health/ Timestamps: 0:00 – intro 1:13 – what is adrenal insufficiency and what causes it? 7:02 – what is adrenal fatigue and how can we reverse it? 11:54 – the drivers of adrenal fatigue and issues with typical treatments 18:51 – the importance of establishing solid diet and lifestyle foundations before adding supplements for adrenal support 24:42 – whether our bodies lose the ability to produce hormones as we age 27:20 – concerns with the use of natural supplements like desiccated adrenal glandulars, licorice, and hormone replacement therapy (HRT) 36:07 – whether the GAPS diet is ideal for healing autoimmune conditions 40:01 – problems with the GAPS diet and other elimination diets 47:37 – the importance of individualizing your gut protocol and the problems with a cookie-cutter approach 52:09 – the connection between gut health, stress hormones, mental health, and autoimmunity 55:40 – how to improve digestion without a gallbladder 59:13 – common issues seen in those without a gallbladder 1:02:08 – long-term consequences of gallbladder removal and how to heal gallbladder issues 1:05:30 – when to use ox bile, TUDCA, taurine, glycine, or vitamin C 1:09:16 – how much fat to include in your diet to stimulate bile flow, and what types of fats are optimal 1:12:55 – strategies for preventing and resolving bile dumping and reflux 1:15:44 – additional consequences of gallbladder removal 1:17:36 – gallbladder issues in relation to hypothyroidism and estrogen dominance

In this episode we discuss: The research behind vitamin A toxicity and whether vitamin A is really a poison Whether you need to be concerned about the use of Accutane Whether retinoic acid is toxic because it’s used as a chemotherapeutic agent Whether Grant Genereux’s claims about vitamin A toxicity are valid Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-120-vitamin-a-toxicity-retinoic-acid-toxicity-accutane-and-whether-hypervitaminosis-a-exists Timestamps: 0:00 – intro 1:15 – why we're examining Grant Genereux's take on vitamin A toxicity and the evidence behind his claims 4:50 – conceptualizing the amount of vitamin A needed for toxicity 7:07 – is hypervitaminosis A (vitamin A toxicity) real? 9:27 – cautioning against the idea of "detox" as an excuse for negative effects and vitamin A toxicity as an unfalsifiable hypothesis 12:36 – is there a conspiracy to poison the masses with vitamin A? 18:36 – how likely is it that you have vitamin A toxicity? 22:30 – problems with the first in vivo study that Grant uses to support vitamin A toxicity 35:14 – vitamin A toxicity in the studies Grant cited require massive doses of vitamin A that would be impossible to obtain from diet 42:44 – Grant’s cited research actually supports the safety of vitamin A 50:52 – more of Grant’s cited research supporting vitamin A safety 58:25 – further research supporting that extremely high doses are required to cause vitamin A toxicity 1:07:57 – whether vitamin A toxicity is driving autoimmunity 1:09:54 – whether retinoic acid is toxic based on concerns regarding the use of Accutane 1:15:40 – how conflating Accutane with retinoic acid is misleading 1:22:12 – whether retinoic acid is toxic because Accutane is used as a chemotherapeutic agent 1:29:37 – evaluating Grant’s claim that retinol automatically becomes “toxic” retinoic acid 1:35:05 – our concluding thoughts on Grant’s arguments regarding vitamin A toxicity

In this episode we discuss: Whether vitamin A toxicity exists and is something you need to be worried about Whether Grant Genereux’s claims about vitamin A deficiency are valid Whether vitamin A is actually a poison rather than a vitamin What we think about the current state of the Ray Peat forum The research on vitamin A deficiencies and whether vitamin A deficiencies exist Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-119-vitamin-a-toxicity-examining-the-evidence-for-vitamin-a-deficiency Timestamps: 0:00 – intro 1:09 – why we’re discussing vitamin A toxicity and Grant Genereux’s perspective 4:53 – closedmindedness within the “low vitamin A” sphere and how it compares to Ray Peat’s work 7:33 – how a low vitamin A diet can have benefits 9:27 – cautioning against the idea of "detox" as an excuse for negative effects and vitamin A toxicity as an unfalsifiable hypothesis 12:33 – the importance of evaluating information objectively while avoiding censorship, tribalism, fearmongering, and religiosity 21:17 – concerns with the current state of the Ray Peat Forum and how to recognize unsubstantiated claims 26:45 – Grant's initial critiques of the original studies on vitamin A deficiency are extremely weak and unsubstantiated 41:48 – introducing Wolbach’s 1925 study on vitamin A deficiency 45:47 – refuting Grant's argument that the retinoic acid in the vitamin-free casein would have caused toxicity 52:35 – refuting Grant's argument regarding confounding variables in lard and butter 1:02:53 – research on vitamin A deficiency and whether vitamin A deficiencies exist 1:20:32 – the necessity of vitamin A for pregnancy, fetal growth, and development

In this episode we discuss: Why serotonin is NOT the “happy hormone” and you may not want to increase it How serotonin and depression relate to stress and energy balance Whether SSRIs are effective for depression How SSRIs actually work, their impact on metabolism, and whether they’re the best treatment option for depression The real drivers of depression and anxiety Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-118-the-truth-about-serotonin-and-ssris-why-serotonin-is-not-the-happy-hormone Timestamps: 0:00 – intro 0:58 – the research showing that serotonin is not the “happy hormone” 4:56 – serotonin’s role in driving the stress state that leads to depression 8:26 – the overlap between anxiety and depression and why they are both characterized by elevated serotonin levels 10:27 – the origins of the idea that serotonin is the “happy hormone” and how serotonin became a marketing tool for pharmaceutical companies 14:49 – serotonin is increased during fasting and starvation and why increasing serotonin should not be our goal 20:16 – serotonin is increased during stress, shock, and infection and leads to learned helplessness 29:04 –SSRIs use in neonates causes depression in adulthood 31:35 – the serotonergic system as an adaptive stress response to a lack of energy 39:09 – serotonin’s role in energy redistribution under stress 43:15 – how SSRIs inhibit mitochondrial respiration, glucose metabolism, and energy production in the brain and liver 47:13 – how SSRIs can reduce symptoms and how the brain responds to SSRIs 52:42 – the true drivers of depression and anxiety 1:01:30 – how serotonin relates to stress hormones, including cortisol, and energy balance

In this episode we discuss: Concerns surrounding fructose malabsorption and whether fructose is really a FODMAP Whether you need to be concerned about excess fructose in foods Whether you should avoid sugar and supplement with fish oil for brain inflammation Diet and supplement strategies for brain injuries The impacts of drinking alcohol from the Bioenergetic view Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-117-fructose-malabsorption-protecting-against-alcohol-and-brain-injuries-and-inflammation-q-and-a Timestamps: 0:00 – intro 1:15 – how fructose gets absorbed in the small intestine 4:24 – the optimal fructose to glucose ratio and how to tell if you have fructose malabsorption 8:41 – the details of how glucose helps with fructose absorption 12:04 – which foods have a high fructose to glucose ratio 16:24 – issues with FODMAP categorization and whether fructose is really a FODMAP 21:23 – listening to your body and understanding individual context vs following rigid “food rules” 27:39 – anti-inflammatory diets and whether we should avoid sugar and supplement with fish oil to reduce brain inflammation 32:06 – dietary and supplement strategies to promote an anti-inflammatory state in the brain 39:15 – the effectiveness of red-light therapy, methylene blue, progesterone, exogenous ketones, and polyphenols in treating brain injuries 44:31 – why we don’t want to prioritize omega 3s in the diet and whether eating fish is any better than fish oil supplementation 47:21 – reducing inflammation with the use of aspirin 47:53 – the main concerns with drinking alcohol: intestinal permeability, endotoxin production, and liver health 52:32 – stress-relieving supplement alternatives to alcohol and the effects of alcohol on vitamins and minerals 54:37 – strategies to mitigate the effects of alcohol in the short-term 58:14 – whether it makes sense to drink alcohol, alcohol use as a coping mechanism, and the impact of culture 1:00:07 – more strategies for mitigating the effects of alcohol in the short and long term

In this episode we discuss: The validity of the counterarguments against the Lipid Energy Model Whether the Lipid Energy Model means that high LDL does not increase cardiovascular disease risk How thyroid and metabolism relate to high LDL on a low-carb diet What the Lean Mass Hyper-Responder phenotype means in terms of metabolic health Whether low-carb diets are ideal for cardiovascular disease health and health in general Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-116-the-truth-about-ldl-and-heart-disease-lmhr-and-the-lipid-energy-model/ Timestamps: 0:00 – intro 1:17 – the primary counterarguments against the Lipid Energy Model 4:15 – BMI, not saturated fat, correlates with the LMHR phenotype 8:15 – eating carbs dramatically lowers cholesterol in LMHR 11:14 – whether Oreos are more effective at lowering cholesterol than statins 17:30 – high cholesterol levels in the LMHR phenotype are not due to excess saturated fat intake or cholesterol production 19:25 – prominent cardiologists and researchers dismissing the lipid energy model due to dogmatism interferes with progress in science and medicine 24:40 – Dr. Shawn Baker’s carbohydrate experiment and contextual considerations when reintroducing carbs into the diet 28:46 – further support for the lipid energy model and the relationship with thyroid function 33:32 – the difference between saturated, monounsaturated, and polyunsaturated fats in relation to lipid profiles 34:40 – whether LDL cholesterol and ApoB cause heart disease and plaque formation 42:18 – how the Lipid Energy Model helps uncover the underlying cause of heart disease 45:15 – LDL levels as a marker of metabolic health rather than a cause of cardiovascular disease and why we may not always want to lower LDL 55:02 – evidence suggesting that LDL does not drive cardiovascular disease 1:05:43 – the difference between high LDL due to metabolic dysfunction and high LDL due to a low-carb diet 1:09:58 – lipid values don’t tell us the whole picture: the Kitavans 1:16:54 – why decreases in insulin, glucose, and HbA1C as well as increased lipolysis and fat oxidation on a low-carb diet is not necessarily a sign of improvement 1:22:57 – increased lipolysis on low-carb diets does not lead to body-fat loss 1:24:25 – whether the Lipid Energy Model proves that low-carb diets are optimal for health

In this episode we discuss: Whether you should be concerned about high LDL or high cholesterol on a low-carb diet The validity of the Lean Mass Hyper-Responder (LMHR) Phenotype and Lipid Energy Model proposed by Dave Feldman The metabolic state that drives the Lipid Energy Model How the "Lean Mass Hyper-Responder" and Lipid Energy Model support the Bioenergetic view of cardiovascular disease Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-115-lmhr-and-the-lipid-energy-model-implications-for-metabolism-and-hormones Timestamps: 0:00 – intro 1:14 – what is the Lean Mass Hyper-Responder (LMHR) phenotype 3:33 – how the Lipid Energy Model challenges the mainstream dogmatic view linking high cholesterol levels to heart disease 6:33 – the protective effects of cholesterol and why it does not cause heart disease, despite being necessary for atherosclerosis 9:49 – the distinction between Lean Mass Hyper-Responders and those with high cholesterol levels in the context of metabolic dysfunction 15:10 – what is the Lipid Energy Model 22:10 – how the body adapts to a lack of carbohydrates, leading to elevated cholesterol levels 27:22 – the hormonal and metabolic state underlying the Lean Mass Hyper-Responder phenotype 32:21 – how adding carbohydrates lowers cholesterol levels in those who don't have metabolic dysfunction at a cellular level 37:11 – whether Lean Mass Hyper-Responders are at increased risk of cardiovascular disease 42:00 – why the Lean Mass Hyper-Responder phenotype isn't ideal: stress and low thyroid function 51:10 – the parallels between the lipid energy model and physiological insulin resistance

In this episode we discuss: How increasing carbohydrate intake actually improves insulin sensitivity, even in people with type 2 diabetes The research showing that fatty liver disease and cardiovascular disease are both characterized by excess fatty acid oxidation The research showing that fatty liver disease and cardiovascular disease are both characterized by excess fatty acid oxidation Why strategies such as intermittent fasting, cold plunges, and OMAD (one meal a day) are not effective for improving insulin sensitivity Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-114-fat-burning-drives-insulin-resistance-and-eating-carbohydrates-improves-insulin-sensitivity/ Timestamps: 0:00 – intro 1:17 – stress hormones (glucagon, epinephrine, and cortisol) are major contributors to insulin resistance and diabetes 4:05 – elevated glucagon levels, not carbohydrates, are the driving force behind high fasting blood glucose levels 6:43 – glucagon is a driver of insulin resistance, while insulin is just a symptom 12:46 – the research showing that blocking stress hormones directly improves insulin sensitivity 15:14 – “hormetic” stressors like intermittent fasting, cause insulin resistance 19:30 – fat burning drives insulin resistance and keeps us in a catabolic state, driving weight gain and muscle wasting 22:15 – cortisol drives insulin resistance and why serum cortisol levels don’t provide the full picture 25:00 – low-carb diets reduce insulin sensitivity while carbohydrate intake improves it 29:40 – decreasing fatty acid oxidation by increasing carb intake improves our ability to tolerate carbohydrates 33:46 – burning fat contributes to increased disease processes and does not lead to losing more body fat 38:04 – fatty acid oxidation damages our mitochondria and increases fat storage 46:22 – type 2 diabetes directly contributes to heart disease by upregulating fatty acid oxidation 52:05 – how to decrease fatty acid oxidation and improve glucose metabolism

In this episode we discuss: Insulin resistance and type 2 diabetes are diseases of excess fat burning and impaired glucose metabolism How increasing carbohydrate intake improves insulin sensitivity, even in people with type 2 diabetes Evidence supporting the bioenergetic view of insulin resistance and type 2 diabetes Why carbs are not actually the cause of insulin resistance and diabetes Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-113-carbohydrates-dont-cause-insulin-resistance-or-diabetes-evidence-for-the-bioenergetic-view Timestamps: 0:00 – intro 1:28 – what the mainstream view of insulin resistance gets wrong when it comes to what causes insulin resistance and diabetes 3:24 – glycolysis and fat oxidation are favored, and glucose oxidation is inhibited in insulin resistance and diabetes 8:39 – what happens to glucose in diabetic cells 10:32 – why insulin resistance is a symptom rather than the driver of diabetes 12:55 – research showing that insulin resistance is driven by poor glucose metabolism 20:50 – impaired glucose uptake is not caused by excess insulin; fat-burning and impaired glucose metabolism are the culprits 27:10 – the problems with relying on fat oxidation over carbohydrate oxidation 30:43 – how increasing blood glucose levels or increasing insulin can restore normal glucose uptake in diabetes 35:28 – how insulin actually lowers blood sugar and the effects of insulin on cortisol and other stress hormones 37:16 - why fatty acid oxidation is NOT the underlying cause of insulin resistance 40:06 – factors that support or block mitochondrial respiration 41:20 – how excess fatty acid oxidation contributes to the pathology of insulin resistance and can impair glucose metabolism over time 42:49 - how insulin actually lowers blood sugar and the effects of insulin on cortisol and other stress hormones (cont.) 47:08 – why we don’t want to blame insulin for insulin resistance and what really causes high fasting blood glucose 49:22 – how low-carb diets increase stress hormones and decrease insulin sensitivity

In this episode we discuss: Why you might want to think twice about using resistant starch for blood sugar regulation and gut health Ways to increase or reduce the amount of resistant starch in the foods you eat How to tell if resistant starch is negatively impacting your gut health, and why non-resistant starch may also pose a problem The optimal calcium to phosphorus ratio according to the research The calcium paradox and why calcium intake doesn’t increase excitation or calcification The hidden dangers of excess phosphorus intake Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-112-the-problems-with-resistant-starch-and-balancing-the-calcium-to-phosphorus-ratio-qa Timestamps: 0:00 – intro 1:00 – mainstream health claims about resistant starch and why we disagree 6:15 – whether there are any benefits to including resistant starch in your diet 11:07 – how to tell if resistant starch is negatively impacting your gut health and how to avoid it 16:05 – which starches are easiest to digest and the factors that affect our ability to digest starches optimally 21:38 – why we should pay attention to our calcium to phosphorus ratio and the risks of high parathyroid hormone levels 26:19 – the optimal calcium to phosphorus ratio and the calcium paradox in terms of regulating blood pressure 31:21 – which phosphorus-containing foods we should avoid to optimize bone density 34:36 – the calcium paradox and why consuming calcium doesn’t increase intracellular calcium

In this episode we discuss: How spore-based probiotics differ from typical probiotics and whether we should be using either of them to improve our gut health Whether low-carb or ketogenic diets are an ideal solution for epilepsy The role of gut health and metabolism in epileptic seizures Concerns with using low- or no-calorie sweeteners Whether stevia is actually any better than artificial sweeteners Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-111-stevia-vs-sugar-ketogenic-diets-for-epilepsy-and-spore-based-vs-standard-probiotics-qa Timestamps: 0:00 – intro 1:17 – whether spore-based probiotics can cause bacterial overgrowths like SIBO 4:53 – the drawbacks of standard probiotic use and the limitations of stool testing 9:55 – how spore-based probiotics protect against pathogenic bacteria and endotoxin and which spore-based product Jay recommends 15:39 – long-term benefits of spore-based probiotics and how long you need to use them for these benefits 21:05 – whether low-carb or ketogenic diets are necessary to improve epilepsy 29:25 – using ketones for fuel and why the production of ketones isn't the problem on a ketogenic diet 30:48 – the main drivers of epileptic seizures and how ketones help to prevent or reverse them 34:17 – the role of the gut microbiome in brain health and epilepsy 42:18 – concerns with low- or no-calorie sweeteners like stevia 48:03 – whether we should be concerned about the lack of nutrients in table sugar, honey, and maple syrup 54:55 – stevia as a potential endocrine disruptor that may have negative effects on the thyroid, liver, and kidneys

In this episode we discuss: Why insulin resistance and diabetes are not caused by excess carbohydrate consumption and are not actually an insulin signaling problem The problems with the idea of metabolic flexibility, earning your carbs, and the carb-insulin model of obesity Why carbs are beneficial even for people who have insulin resistance or diabetes The role of fat burning and stress in driving insulin resistance Specific diet, movement, and supplement recommendations to reverse insulin resistance and diabetes Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-110-the-true-cause-of-insulin-resistance-and-diabetes-from-the-bioenergetic-view/ Timestamps: 0:00 – intro 1:14 – metabolic flexibility, earning your carbs, the carb-insulin model of obesity, and dispelling other common insulin resistance myths 7:48 – low-carb, keto, and carnivore diets may improve symptoms but are not the solution for insulin resistance 13:13 – what the mainstream views of insulin resistance gets wrong when it comes to what causes insulin resistance 15:50 – why you might not want to use a continuous glucose monitor and the unnecessary fear of blood glucose spikes 17:48 – whether insulin is harmful and whether we want to keep insulin levels as low as possible 22:15 – whether we can restore optimal insulin sensitivity without low-carb diets 25:16 –the bioenergetic view of insulin resistance 27:12 – insulin resistance as an adaptive evolutionary process that is crucial for survival 31:22 – the difference between physiological and pathological insulin resistance 34:40 – how inhibited glucose oxidation causes insulin resistance 40:46 – how fatty acid oxidation causes increased production of ROS, slows cellular respiration, and blocks glucose oxidation (The Randle Cycle) 51:06 – the harms of ROS production from fatty acid oxidation and other forms of stress 53:04 – insulin resistance as an energy deficient state 54:19 – insulin resistance is not an insulin signaling problem, it’s an energy production problem 58:30 – the role of stress hormones (like cortisol) in insulin resistance 1:02:09 – how insulin and carbohydrates decrease stress 1:05:59 – how to fix insulin resistance and restore insulin sensitivity by fixing our capacity to produce energy 1:10:38 – specific diet, movement, and supplementation recommendations for insulin resistance and diabetes 1:17:55 – why you don’t need to tailor your carb intake to your carb tolerance

In this episode we discuss: Our thoughts on Chris Palmer’s “Brain Energy” theory of mental health Why low carb diets are not the solution for anxiety and depression and what to do instead What most people miss when it comes to weight loss and why we shouldn’t focus on fat-burning Strategies to optimally manage blood sugar for Type 1 Diabetes Whether we should lower our fat intake to lose weight Sign up for the Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Click here to check out the show notes: https:/jayfeldmanwellness.com/ep-109-chris-palmers-brain-energy-type-1-diabetes-and-low-fat-diets-for-weight-loss-qa Timestamps: 0:00 – intro 1:19 – our take on Chris Palmer's “Brain Energy” theory of mental health disorders 5:04 – challenging the misconception of a separation between the brain and body 8:03 – why low-carb, ketogenic, and carnivore diets can produce temporary mental health benefits 10:36 – how impaired energy production underlies poor brain health and how to fix it without using low-carb diets 14:05 – how fat burning can temporarily relieve symptoms of poor glucose utilization (with a major cost) 18:29 – why fatty acid oxidation is our default metabolic state under stress and underlies all chronic disease 22:20 – whether ketogenic diets promote metabolic flexibility 24:53 – poor glucose metabolism as a driver of Alzheimer’s disease and other mental health conditions 28:13 – the adaptive benefit of burning fat during stress 31:31 – blood sugar management for Type 1 Diabetes and whether a low-carb diet is optimal 38:13 – whether lowering fat intake is necessary for burning and losing fat 42:09 – whether improving metabolic function alone is enough to reduce stored fat and when a decrease in dietary fat intake may be necessary 47:32 – the difference between subcutaneous fat and visceral fat and their potential implications 50:34 – how to fix our hunger signals to prevent excessive eating 54:33 – weighing the costs of extreme diets and the need for more innovative thinking around health

In this episode we discuss: The unexpected costs of using excess exercise to lose weight Our thoughts on Herman Pontzer’s book Burn and the Constrained Model of Energy Expenditure Our thoughts on Ted Naiman’s protein to energy ratio diet (PE Diet) The cost of eating too much protein and what to do instead How to increase caloric intake to raise your metabolism and reverse hypothyroidism The major category of nutrients that’s often missed for optimizing mitochondrial function Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Click here to check out the show notes: https:/jayfeldmanwellness.com/ep-108-herman-pontzers-burn-ted-naimans-pe-diet-and-increasing-calorie-intake-to-raise-metabolism-qa/ Timestamps: 1:25 – Herman Pontzer’s Constrained Model of Energy Expenditure and the adverse effects of energy deficits 7:13 – problems with the additive model of energy expenditure and the physiological cost of excess exercise 10:40 – environmental factors that we can change to increase metabolism 16:42 – the unexpected costs of using excessive exercise to lose weight 19:16 – weight gain as an adaptive response to an energy deficit 22:46 – when eating too much can be a problem and how to identify your ideal calorie intake 32:18 – Ted Naiman’s protein to energy ratio diet and optimal protein intake 41:13 – the problems with using protein as an energy source 46:45 – how to increase caloric intake to raise metabolism and reverse hypothyroidism 50:47 – how to track your symptoms and progress to better guide your nutrient goals 56:55 – the best foods for increasing calorie intake and what to do if you have a low appetite 1:00:30 – the essential role of both macro and micronutrient density in promoting mitochondrial health 1:04:00 – why sugar cravings are not the same as sugar addiction 1:06:46 – easy ways to incorporate more macro and micro nutrient dense foods into your diet

In this episode we discuss: Studies showing that omega-3 consumption decreases lifespan and increases disease processes The potentially harmful effects of omega-3 usage during pregnancy on offspring The impact of omega-3s on inflammation, endotoxin, and mitochondrial respiration The data in native cultures showing that omega-3 intake doesn’t improve cardiovascular disease or mortality Extremely healthy populations that consume high-carb and high-saturated fat diets with almost no omega-3s Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/ Click here to check out the show notes: https:/jayfeldmanwellness.com/ep-107-omega-3s-decrease-lifespan-and-increase-disease Timestamps: 0:00 – intro 1:30 – studies showing that omega-3 consumption decreases lifespan and increases disease processes in animals 13:55 – studies on animals showing the harmful effects of omega-3 consumption during pregnancy on offspring 17:37 – studies showing that omega-3 consumption contributes to disease processes, increases inflammation, causes oxidative stress, increases endotoxin, and interferes with mitochondrial respiration 29:23 – whether we should be concerned about saturated fats increasing endotoxin absorption 30:33 – how omega-3 consumption leaves us more susceptible to damage when we’re under stress 33:52 – whether we should be consuming fatty fish 37:00 – the lack of benefit of omega-3 consumption in native populations consuming large amounts of fatty fish and seafood 46:14 – low incidence of cardiovascular disease in native populations consuming very little omega-3s 1:05:18 – concluding thoughts on whether we should consume omega-3s based on the data on omega-3s in RBCs and phospholipids and mortality

In this episode we discuss: Studies showing that fish oil and cod liver oil supplementation increase oxidative damage in humans, even in the triglyceride form alongside antioxidants Why omega-3s are harmful in both healthy and unhealthy humans The harmful metabolic and hormetic effects of omega-3s (and why omega-3s aren’t beneficial due to hormesis) The research showing that omega-3s do not improve chronic health conditions or mortality in humans Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Click here to check out the show notes: https:/jayfeldmanwellness.com/ep-106-omega-3s-increase-inflammation-and-oxidative-stress/ Timestamps: 0:00 – intro 1:26 – a summary of the harmful effects of omega-3 consumption in humans 9:14 – omega-3 consumption amplifies the damage from stress (including fasting) 17:08 – vitamin E does not protect against lipid peroxidation from fish oil consumption 20:06 – studies showing that increased omega-3 consumption (including fish oil and cod liver oil) in humans and other animals increases lipid peroxidation, even in triglyceride form 31:45 - how omega-3s triggers hormesis, and why this doesn’t make omega-3s beneficial 39:50 – the context of the omega-3 research and its application 42:57 – studies showing that omega-3 supplementation doesn’t improve chronic health conditions or reduce mortality in humans

In this episode we discuss: Whether the research suggesting that omega-3s decrease mortality is valid Omega-6 intake as a major confounding variable when looking at omega-3 research The dramatic lifespan-lowering effect of omega-3s and total PUFA across all species How omega-3s increase susceptibility to oxidative stress and damage Looking at the Masai diet as an example of a low-omega-3 diet with high omega-3s in the red blood cells Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Click here to check out the show notes: https://jayfeldmanwellness.com/ep-105-challenging-the-idea-that-increased-omega-3-consumption-lowers-mortality/ Timestamps: 0:00 – intro 1:35 – why we’re discussing omega-3s and lifespan 8:10 – the studies showing an association between omega-3 content in phospholipid and reduced mortality 16:48 – conflict of interest as a confounding variable in these studies 18:12 – healthy user bias as a confounding variable in these studies 20:46 – omega-6 consumption as a confounding variable in these studies 29:04 – problems with using RBC phospholipids and serum fatty acids as markers of fatty acid composition of the diet 30:35 – a low omega-6 diet will increase omega-3 content in the RBC phospholipids and serum fatty acids 36:35 – the effect of heritability on RBC phospholipid and serum fatty acid composition 43:58 – the effect of oxidative stress on RBC phospholipid and serum fatty acid composition 52:57 – why it’s important to consider interventional studies and other research to determine whether we should increase omega-3 consumption to reduce mortality 55:30 – research looking at the relationship between composition of phospholipids and lifespan across species 1:07:33 – research looking at the relationship between composition of phospholipids and lifespan within species 1:23:30 – increased consumption of omega-3s increases omega-3 content in phospholipids and therefore the peroxidizability index 1:28:53 – looking at the Masai diet: low omega-6 intake increases omega-3 content in RBC fatty acids

In this episode we discuss: Individualism and competition vs. collaboration and communitarianism Whether humans are inherently selfish and destructive The cost of social media and other forms of distraction How drugs and alcohol can function as numbing agents Why many causes that appear worthy turn out to be distractions from the real problems Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/ Click here to check out the show notes: https://jayfeldmanwellness.com/ep-104-how-western-culture-keeps-us-distracted-and-fighting-amongst-ourselves/ Timestamps: 1:14 – individualism and competition vs. collaboration and communitarianism 25:45 – randomness, subjectivism, moral relativism, and the resulting nihilism 31:20 – the consequences of the idea that humans are selfish, destructive, and useless other than what we can produce 41:39 – how potentially beneficial advancements become co-opted to maintain the current power structure 48:04 – how western culture degrades esteem and prevents self-actualization 49:43 – the many aspects of modern technology and entertainment that distract us from what’s important 55:26 – how drugs and alcohol can also function as numbing agents 1:03:42 – how worthy causes become co-opted to prevent legitimate progress 1:13:18 – contrasting with cultures that are family-oriented and less distracted by technology 1:16:10 – the effects of culture in science, health, and everyday life

In this episode we discuss: How lower wages and higher costs have dramatically reduced our quality of life How we’ve ended up working more and resting less with worse outcomes Whether advancements in technology have improved the quality of life of the average person How marketing and consumerism keep us on the hamster wheel The hidden costs of convenience culture Concerns surrounding the collusion between government and corporations How divide and conquer tactics convince us to blame each other rather than the powers that oppress us Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/ Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://jayfeldmanwellness.com/ep-103-how-western-culture-keeps-us-poor-and-destroys-our-family-community-and-relationships/ Timestamps: 1:34 – how western culture degrades safety and security through financial means 7:33 – how lower wages with higher costs reduces safety and forces people to prioritize work over quality of life 15:14 – we currently work more with less leisure time than ever before, with worse outcomes 20:24 – the cost of consumer culture and marketing as an engine that drives consumerism 30:53 – the cost of convenience culture: freedom, privacy, morals, ethics, and health 36:14 – the problems with profit-driven motives and the collusion between government and corporations 45:36 – how western society has become fragile and unstable 51:13 – how western culture degrades relationships and feelings of love and belonging 52:41 – continued how western culture degrades relationships and feelings of love and belonging 53:27 – divide and conquer tactics within western culture and encouraging the “us vs. them” mentality