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#085 Dr. Peter Attia on Mastering Longevity – Insights on Cancer Prevention, Heart Disease, and Aging

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Show notes are available by clicking here

Peter Attia, MD is a highly respected expert in preventive medicine, focused on the crucial subject of longevity and cardiovascular health. He's also the author of the NY Times best selling book Outlive - which I highly recommend if you have not read it already. Peter's philosophy transcends the conventional goal of merely extending lifespan; it's about enriching the quality of every year, ensuring that each stage of life is lived with optimal health and vitality.

In this episode, we discuss:

  • (00:07:36) Defining cardiovascular disease
  • (00:09:43) Coronary plaque and fatality risk
  • (00:11:09) What is cholesterol?
  • (00:13:34) How ApoB predicts heart disease
  • (00:21:34) Factors elevating ApoB
  • (00:25:24) ApoB reference range explained
  • (00:27:23) Does high ApoB cause cardiovascular disease
  • (00:37:01) ApoB thresholds for ASCVD prevention
  • (00:40:27) Dietary factors raising ApoB
  • (00:39:33) Genetics of ApoB and LDL
  • (00:53:24) Does low LDL increase cancer?
  • (00:56:19) Cholesterol-lowering drugs
  • (00:59:59) Statins, uses, and side effects
  • (01:03:12) Are statins toxic to mitochondria?
  • (01:09:56) Ubiquinol for statin-induced muscle soreness
  • (01:11:09) How to train in zone 2
  • (01:17:09) Statins and neurodegenerative disease risk
  • (01:21:54) Cholesterol synthesis in the brain (desmosterol role)
  • (01:25:58) Statin alternatives – pros and cons
  • (01:27:30) Ezetimibe
  • (01:31:01) Bempedoic acid
  • (01:36:49) Berberine for CVD Risk Reduction?
  • (01:39:36) Muscle as a glucose sink
  • (01:45:58) Chronic glucose toxicity and vascular impact
  • (01:51:38) Hemoglobin A1C Levels and Mortality Data
  • (01:55:35) 80/20 Zone 2/VO2 Max Training Protocol
  • (02:02:12) Insights from VO2 max testing data
  • (02:12:17) How obesity increases cancer risk
  • (02:15:03) Cancer screening benefits and risks
  • (02:20:47) Dr. Attia's recommended cancer screening age
  • (02:28:54) Liquid biopsies for detecting cancer
  • (02:34:48) CT scans, mammograms and radiation concerns
  • (02:40:32) Menopause – hormonal shifts and health effects
  • (02:45:13) Hormone replacement therapy (HRT)
  • (02:58:57) Perimenopause diagnosis with hormone levels
  • (03:02:04) HRT's impact on dementia, cancer, and heart disease risk
  • (03:04:49) Estrogen's role in bone density
  • (03:07:42) Vitamin D
  • (03:16:24) Testosterone replacement for women's sexual function
  • (03:18:47) HRT safety 10 years post-menopause
  • (03:23:05) Treating low testosterone in men
  • (03:29:53) TRT side effects and risks
  • (03:32:33) Ways to reduce blood pressure
  • (03:39:33) How to measure blood pressure
  • (03:45:30) Peter's longevity optimization routines

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