Rob Mac Sweeney chats with Jessica Spence about the B-FREE trial, investigating benzodiazepine-free anaesthesia for the prevention of delirium in cardiac surgery

Bala Venkatesh (Brisbane) hosts a panel discussion entitled "Beyond Platform Trials" at the Critical Care Reviews Meeting 2023. The panellists include Bronagh Blackwood (Belfast), Susan Rowell (Chicago), Fernando Zampieri (Edmonton), Marion Campbell (Aberdeen), David Harrison (London), Roger Lewis (Los Angeles), Derek Angus (Pittsburgh) & Kathy Rowan (London).

Kathy Rowan (London) hosts a fascinating panel discussion on causality at the Critical Care Reviews Meeting 2023. The panellists include Bronwen Connolly (Belfast), Ewan Goligher (Toronto), Flavia Machado (Sao Paulo), Kath Maitland (Kalifi), John Norrie (Edinburgh), Victoria Cornelius (London), Andrew Althouse (Pittsburgh) and Chris Seymour (Pittsburgh).

Dr Lisa Higgins (Melbourne) presents the long term outcomes of the REMAP-CAP domains at the Critical Care Reviews Meeting 2023. Prof Howard Bauchner (Boston) delivers an editorial. Prof Christopher Seymour (Pittsburgh) chairs the session.

Nina Christine Andersen-Ranberg presents the AID-ICU trial, investigating haloperidol for the management of delirium in the ICU. Danny McAuley delivers an editorial. Anders Perner joins the discussion and the session is chaired by Paul Mouncey.

Prof Flavia Machado (Sao Paulo) delivers the John Hinds Lecture at the Critical Care Reviews Meeting 2023, describing the story of BRICNET, the Brazilian Critical Care Trials Group. The session commences with Dr Chris Nutt remembering our friend, Dr John Hinds.

You're listening to the audio version of the PROCOAG trial presentation from the Critical Care Reviews Meeting 2023. The PROCOAG trial investigated the efficacy and safety of early administration of 4-factor prothrombin complex concentrate in trauma patients at risk of massive transfusion. The trial is presented by Pierre Bouzat from Grenoble. Susan Rowell from Chicago, delivers the editorial. The session is chaired by Chris Seymour (Pittsburgh). PROCOAG was published in JAMA in March 2023.

You're listening to the audio version of the TEAM trial presentation from the Critical Care Reviews Meeting 2023. The TEAM trial investigated early active mobilisation in critically ill mechanically ventilated patients. The trial is presented by Carol Hodgson from Melbourne. Darren Taichman from Philadelphia, delivers the editorial. The session is chaired by Paul Mouncey (Pittsburgh).

Matthew Semler (Nashville, USA) presents the PILOT trial at the Critical care Reviews Meeting 2023, in Titanic Belfast. The PILOT trial compared low, intermediate and high oxygenation targets in critically ill mechanically ventilated patients. Kath Maitland from Kigali, Kenya, delivers an independent editorial. The session is chaired by Chris Seymour from Pittsburgh, USA. PILOT was published in the New England Journal of Medicine on November 10th, 2022.

Dr Francois Lamontagne joins Rob Mac Sweeney to discuss the harmonised REMAP-CAP / LOVIT-COVID vitamin C trial. The trial was presented at the European Society of Intensive Care Medicine annual congress and simultaneously published in the New England Journal of Medicine.

The Critical Care Reviews Podcast discusses the biggest critical care trials, either planned or in progress, with their chief investigators. It's hosted by Rob Mac Sweeney, an intensivist in Belfast, Northern Ireland. We also release audio versions of the presentations from the Critical Care Reviews Meetings and ad hoc livestreams

Mark Peters and Doug Gould (both London) present the results of the OXY-PICU trial, comparing conservative with liberal oxygenation targets (SpO2 88-92% vs >94%) in critically ill children receiving invasive mechanical ventilation. Luregn Schlapbach (Zurich) delivers an independent editorial. They are joined by Victoria Cornelius (London), Bronagh Blackwood (Belfast), & Matthew Semler (Nashville) for a panel discussion. The session is chaired by Howard Bauchner (Boston).

Scott Berry (Austin) and Danny McAuley (Belfast) join Rob Mac Sweeney to discuss the results of the statin domain of the REMAP-CAP trial, investigating 80mg once daily of simvastatin in critically ill patients with COVID-19.

Jan Jansen (Birmingham, USA) & Marion Campbell (Aberdeen) present the results of the UK-REBOA trial, investigating the use of REBOA in trauma patients with severe non-compressible torso haemorrhage. The editorial is delivered by John Holcomb (also from Birmingham, USA) and the session is chaired by Catriona Kelly from Dublin. The panel discussing the trial are Diana Cimpoesu (Ilsa, Romania), Caroline Leech (Coventry), Stephen Bernard (Melbourne) and Roger Lewis (Los Angeles).

Profs Nikki Curry (Oxford) and Karim Brohi (London) present the results of the CRYOSTAT-2 trial, evaluated early & empiric high-dose cryoprecipitate in patients with major traumatic haemorrhage. The editorial is delivered by Susan Rowell (Chicago) and the session is chaired by Phil Gillen from Belfast. The panel discussing the trial are Russell Gruen (Canberra), Caroline Leech (Coventry), John Holcomb (Birmingham, USA), Andrew Althouse (Pittsburgh) and co-investigator Simon Stanworth from Oxford.

Prof Ivor Douglas (Denver, USA) presents the CLOVERS trial, comparing an early restrictive fluid strategy with an early liberal fluid strategy in adult patients with sepsis-induced hypotension. Prof Fernando Zampieri (Edmonton, Canada), delivers an editorial. The session is chaired by Dr Paul Mouncey (London, England).

Russell Gruen, Brian Burns and Stephen Bernard present the results of the PATCH-Trauma trial, investigating tranexamic acid in severe trauma. An independent editorial is delivered by Karim Brohi (London). Caroline Leech (Coventry) chairs a panel discussion consisting of Susan Rowell (Chicago), Carol Hodgson (Melbourne), John Holcomb (Birmingham, USA) and John Norrie (Edinburgh).

Glenn Eastwood presents the results of the TAME cardiac arrest trial, investigating mild hypercapnoea post cardiac arrest. He is joined by senior investigators Alistair Nichol (Dublin) and Stephen Bernard (Melbourne). An independent editorial is delivered by Lars Andersen (Aarhus). Darren Taichman (Philadelphia) chairs a panel discussion consisting of Flavia Machado (Sao paulo), Joyce Yeung (Birmingham, UK) and Andrew Althouse (Pittsburgh), as well as the other speakers.

Profs Matthew Prekker (Minneapolis) and Matthew Semler (Nashville) present the results of the DEVICE trial, comparing direct with video laryngoscopy for emergency intubation in the critically ill. Prof Ellen O'Sullivan (Dublin) delivers an editorial, followed by a panel discussion including Prof David Harrison (London), Dr Caroline Leech (Coventry), Dr Fiona Kelly (Bath) and Prof Alistair Nichol (Dublin). The session was chaired by Dr Catriona Kelly (Dublin). These results were presented at the Critical Care Reviews Meeting 2023, held in Titanic Belfast on June 16th. The DEVICE trial was simultaneously published in the New England Journal of Medicine.

Profs Giovanni Landoni and Giacomo Monti present the results of the MERCY trial, comparing bolus administration with continuous infusion of meropenem in critically ill patients with sepsis and septic shock. The results were presented at the Critical Care Reviews Meeting 2023, in Titanic Belfast. Prof Flavia Machado (Sao Paulo) delivers an editorial. The panel discussion incldues Profs Kathy Rowan (London), Victoria Cornelius (London), Ivor Douglas (Denver) and Ewan Goligher (Toronto). The session was chaired by Chris Nutt (Belfast).