About the podcast FoundMyFitness
A podcast about health, science, nutrition, aging, and fitness.
#069 COVID Vaccine Myths, Questions, and Rumors with Rhonda Patrick and Roger Seheult
In this nearly 2.5-hour episode, Dr. Rhonda Patrick and Dr. Roger Seheult and Kyle Allred of MedCram make a thoughtful, merit-based, and truly comprehensive discussion of COVID-19 vaccination. In addition to being a co-founder of MedCram Medical Lectures, Dr. Roger Seheult is, as you will find out in the conversation, a boots on the ground, critical care pulmonologist. For Dr. Seheult, COVID-19 is not just theory. He sees real sick people and for that reason brings a very special context to this conversation. Furthermore, Dr. Seheult is also an academic and educator. He is an Associate Clinical Professor at the University of California, Riverside School of Medicine and an Assistant Clinical Professor at the School of Medicine and Allied Health at Loma Linda University. He is quadruple-board certified in Internal Medicine, Pulmonary Diseases, Critical Care Medicine and Sleep Medicine through the American Board of Internal Medicine. In this episode, we discuss: Vaccination in the young and healthy Long-haul COVID Spike protein cytotoxicity COVID-19 Vaccine Adverse Event Reporting System (VAERS) Antibody-dependent enhancement Fertility and biodistribution data Whether or not mRNA vaccines alter human DNA Current ivermectin evidence Delta-variant and breakthrough infections Viral evolution (virulence vs. immune escape) T-cell immunity vs. antibody immunity Watch the annotated video: https://www.youtube.com/watch?v=pp-nPZETLTo Subscribe to MedCram on Apple Podcasts: https://podcasts.apple.com/us/podcast/medcram/id1564795918 Subscribe to MedCram on YouTube: https://www.youtube.com/channel/UCG-iSMVtWbbwDDXgXXypARQ
#068 Dr. Bill Harris on omega-3 fatty acids, cardiovascular health, and inflammation
Dr. William ("Bill") Harris is one of the world's preeminent experts in the field of omega-3 fatty acid research. His work has focused on the roles that fatty acids in play in cardiovascular and neurocognitive health. The author of more than 300 scientific papers on fatty acids and health, Dr. Harris is a professor in the Department of Medicine in the Sanford School of Medicine at the University of South Dakota, the co-inventor of the Omega-3 Index, founder of OmegaQuant Analytics, and president and founder of the Fatty Acid Research Institute. In this episode, Dr. Harris and I discuss… How early studies on dietary fats and cholesterol levels spawned the field of omega-3 research. How standards of "normal" bleeding time may be abnormally high in Western countries, leading to some misconception on the effects of omega-3. How different types of omega-3s, such as alpha-linolenic acid, share structural similarities with marine omega-3s but not the same cardioprotective effects. How genetic engineering of plants may yield abundant, sustainable omega-3s in the future. What the omega-3 index test is, how it was created, and how it reveals individual variations in how much omega-3 we may need. How red blood cell concentration of omega-3s better reflect long-term omega-3 status. How the omega-3 index may predict life expectancy. How genetic variants influence omega-3 dietary needs. How metabolites of omega-3 metabolism reduce and resolve inflammation. How people with high omega-3 concentrations were half as likely to die from COVID-19. How the omega-3 DHA may help keep the SARS-CoV-2 spike protein from entering cells. How concerns over the omega-6/omega-3 ratio may be unfounded, and it really may boil down to just how much omega-3 you're taking in. Looking for more? Join over 300,000 people and get the latest distilled information on sleep, depression, and fasting straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
#067 Dr. Ashley Mason on Drug-free Approaches for Treating Depression, Insomnia, and Overeating
Dr. Ashley Mason is a clinical psychologist and director of the Sleep, Eating, and Affect Laboratory at the Osher Center for Integrative Medicine at UCSF. Her research centers on nonpharmacological approaches for treating depression, insomnia, and overeating. In this episode, you’ll hear Rhonda and Ashley discuss: 08:10 - How whole-body hyperthermia (WBH) and sauna use differ. 17:06 - How people with depression have thermoregulatory dysfunction – but sauna use may correct it. 21:12 - How WBH and sauna use may reduce symptoms of depression. 33:22 - How heating the body slowly may improve heat tolerance and increase WBH effectiveness. 39:35 - How sauna use may benefit people with depression and cardiovascular disease – which often coincide. 40:18 - How Dr. Mason and I are collaborating on a new research project to measure biomarkers associated with depression and WBH. 44:19 - How sauna bathing and similar practices often provide opportunities for people to connect socially. 53:12 - How insomnia differs from being a "night owl." 57:10 - How insomnia often arises from major changes in a person's life. 01:01:26 - How cognitive behavioral therapy, sleep hygiene, stimulus control, and sleep restriction can help treat insomnia without drugs. and so much more! Looking for more? Join over 300,000 people and get the latest distilled information on sleep, depression, and fasting straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
#066 Dr. Mark Mattson on the Benefits of Stress, Metabolic Switching, Fasting, and Hormesis
Dr. Mark Mattson Dr. Mark Mattson is a professor of neuroscience at the Johns Hopkins University School of Medicine and the former chief of the Neuroscience Research Laboratory at the National Institute on Aging. He's one of the most cited neuroscientists in the world, with more than 180,000 citations noted in the scientific literature. Dr. Mattson's work has advanced scientific understanding of brain aging and identified fundamental aspects of neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease. His most notable work has focused on how the brain responds to mild stressors, such as those associated with exercise and intermittent fasting. In this episode, Dr. Mattson and I discuss... How hormetic stressors drive adaptation and prevent physiological complacency. How intermittent fasting improves health by promoting metabolic switching. How daily time-restricted eating and 5:2 weekly fasting compare. How a ketogenic diet and intermittent fasting differ in terms of brain effects. How exercising while intermittent fasting exerts additive effects. How plant-based bioactive compounds induce hormetic stress. How severe caloric restriction may harm the body and compromise muscle mass. The differing contexts of intermittent fasting: young vs. old and in men vs. in women. How the effects of cortisol differ during a fast versus chronic uncontrollable stress. How the effects of fasting-mimetics like resveratrol and spermidine compare with actual fasting, and; How ketone supplementation may improve brain health Show notes coming soon! Join over 300,000 people and get the latest distilled information on circadian insights straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
#065 Dr. Satchin Panda on Circadian Insights into Exercise Timing, Melatonin Biology, and Peak Cognition
Dr. Satchidananda (Satchin) Panda is a professor in the Regulatory Biology Laboratory at the Salk Institute for Biological Studies. His work focuses on chronobiology, the study of the day-night cycles that drive the multifaceted activities of the human body, using genetic, genomic, and biochemical approaches. He is an expert on circadian rhythms and a pioneer in the field of time-restricted eating. A priority for Dr. Panda when designing his studies is to identify strategies that positively impact public health. Circadian rhythms, the body’s 24-hour cycles of biological, hormonal, and behavioral patterns, modulate a wide array of physiological processes, including the body’s production of hormones that regulate sleep, hunger, and metabolism, ultimately influencing body weight, performance, and susceptibility to disease. Circadian rhythmicity may have profound implications for human healthspan. When and how much we sleep, eat, or exercise (and these activities’ effects on our health) are intrinsically linked to our circadian rhythms. In this episode, Dr. Panda and I discuss... 05:31 - How circadian rhythms influence human health. 12:30 - How seeking bright light in the morning and avoiding it in the evening can help us sleep better. 20:40 - How the ability of supplemental melatonin to counteract evening bright light exposure varies. 26:16 - How understanding the relationship between melatonin and insulin secretion might help us decide when to eat. 33:15 - How shift work, jet lag, and modern lifestyles contribute to altered circadian rhythms and metabolic dysfunction. 45:10 - How naps might aid with afternoon sleepiness and sleep loss. 47:05 - How we can tailor our indoor lighting environment to promote healthy circadian rhythms. 51:20 - How time-restricted eating (eating within a narrow time range) can be beneficial. 01:02:13 - How Dr. Panda’s ongoing study uses a smartphone app to track when people eat. 01:03:41 - How most people are unaware of their eating patterns. 01:07:58 - How Dr. Panda incorporates his research findings into his own life. 01:16:21 - How our circadian rhythms dictate when we should exercise – and how caffeine provides a workaround. Read the full show notes to learn more: https://www.foundmyfitness.com/episodes/satchin-panda-3 Sign up to receive Rhonda’s regular newsletter: https://www.foundmyfitness.com/newsletter Become a FMF Premium Member to receive exclusive podcasts, emails, and more: https://www.foundmyfitness.com/crowdsponsor
#064 Dr. Michael Snyder on Continuous Glucose Monitoring and Deep Profiling for Personalized Medicine
Dr. Michael Snyder is the director for the Center for Genomics and Personalized Medicine at Stanford and a pioneer and advocate of "deep profiling." Deep profiling seeks to apply intelligent analysis to large data sets to yield specialized clinical insight, ranging from common consumer-grade wearables like Apple Watches to whole-body MRI, continuous glucose monitoring, and metabolomics. Chapters: 00:12:51 - Continuous glucose monitors 00:31:04 - Lyme disease 00:34:00 - Predicting illness with smartwatches 00:39:14 - Heart rate variability 00:40:41 - Exposome and airborne pollutants 00:51:04 - Discovering Ageotypes 00:58:05 - Exercise benefits 01:03:11 - Michael Snyder's lifestyle habits Get this show's notes, timeline, and transcript: https://www.foundmyfitness.com/episodes/michael-snyder Dr. Snyder's faculty bio page: https://profiles.med.stanford.edu/michael-snyder Dr. Snyder on Twitter: https://twitter.com/SnyderShot COVID-19 Tracking Study: https://innovations.stanford.edu/wearables Free metabolism SNP report for consumer genetic data: https://www.foundmyfitness.com/genetics/metabolism
#063 Dr. Roger Seheult from MedCram on COVID-19 Vaccines, Vitamin D, and Heat Hydrotherapy
Dr. Roger Seheult is the co-creator of MedCram Videos. In the early days of the COVID-19 pandemic, MedCram emerged as a beacon of insight, providing continuing coverage and perspectives in an environment almost defined by information scarcity. What particularly excited me about the unique opportunity of this interview is that apart from Dr. Seheult being a unique voice of public scholarship during the early days of the pandemic, he's also a quadruple board-certified pulmonologist with deep experience working on the frontline of the COVID-19 pandemic. In other words, when it comes to COVID-19 for Dr. Seheult... it's personal. He has worked tirelessly not just to help people find their way back to wellness as a critical care provider, but he broadcasts the insights he has gained realtime to the 1 million subscribers listening to his medical lecture platform he co-founded with physician assistant Kyle Allred. Listen to this episode to hear Dr. Seheult's thoughts on: 00:06:20 - How MedCram Videos got started and the future of medical education from Dr. Seheult's standpoint. 00:09:37 - What to do when life is on the line and the usual hierarchy of evidence doesn't exist, as in early emergency COVID-19 treatment. 00:12:46 - The crucial differences in treating early vs. late-stage COVID-19 illness. 00:14:40 - How doctors would've treated COVID-19 one-hundred years ago. 00:18:13 - How increasing ventilation may powerfully impact COVID-19 disease transmission and why airplanes have surprisingly little disease transmission. 00:20:28 - How masks are virtually universally beneficial in the pandemic regardless of type. 00:21:32 - Vitamin D and COVID-19 00:22:22 - How the steroid chemical structure of vitamin D confers qualities on vitamin D that other vitamins ("vital amines") do not possess, such as membrane permeability that provides access to the nucleus and broad gene regulatory effects mediated by a specialized vitamin D receptor element. 00:23:24 - How calcium homeostasis, which was the early and exclusive focus for scientists and doctors that were trying to determine the ideal vitamin D levels, may have caused the RDA to be set too low since we now know vitamin D regulates around 5% of the protein-encoding genome and have much broader effects. 00:24:23 - How the hormonal role of vitamin D confers on it properties more similar to other hormones like testosterone and cortisol rather than those of ordinary vitamins. 00:26:21 - The surprising level of overlap between COVID-19 positivity and groups most affected by vitamin D deficiency and the surprise finding of how less than 50 ng/mL blood levels of vitamin D associated with greater likelihood of SARS-CoV-2 positivity in the hospital. 00:30:27 - How scientists are able to interrogate the effects of low vitamin D levels through genetic research, a type of study known as mendellian randomization. 00:34:20 - The gene regulatory effects of vitamin D and the implications for the scale of its biological impact. 00:35:49 - How Vitamin D's ACE2/renin-angiontensin-promoting effects may be mechanistically involved in the effects observed in vitamin D COVID-19 studies. 00:42:00 - Why ameliorating vitamin D deficiency in one large monthly bolus might be less effective than daily or weekly doses. 00:43:23 - How a prescription-only form of vitamin D known as Calcifediol might have an advantage in acute care for COVID-19. 00:47:06 - Why skin synthesis of vitamin D from UV B radiation can be extraordinarily unreliable when compared to supplementation. 00:53:43 - What the safest dose range for vitamin D is that should also address deficiency in most populations. 01:06:15 - The beneficial circadian effect of early morning sunlight. 01:07:38 - How sleep deprivation is meaningfully implicated in profound and immediate impairment of viral immunity. 01:12:08 - Dr. Seheult's suggestions for how to achieve the highest quality of sleep. 01:19:18 - How a century old sanitarium technique used during the Spanish flu era massively boosts interferon by up to ten-times using heat exposure. 01:22:38 - How genetic and antibody-induced failures of the interferon system underpin up to 14% of all severe cases of COVID-19 and why interferon is so vitally important for viral response. 01:26:43 - Why treating the symptoms of fever during the spanish flu turned out to not be a good idea, immunologically speaking. 01:31:58 - Dr. Seheult's on-going research into using hot hydrotherapy as a viral immunity booster. 01:47:00 - COVID-19 Vaccines Here's some web pages related to the show and this episode that we think you should check out... You can access the show's notes, timeline, and transcript here. Try out a preview of our premium podcast The Aliquot Preview. Learn about FoundMyFitness premium membership and our twice-per-month science news updates we send out just to members called the Science Digest.
#062 Dr. Steve Horvath on epigenetic aging to predict healthspan: the DNA PhenoAge and GrimAge clocks
Consistent patterns of age-based alterations in DNA methylation can be harnessed to estimate age, serving as a sort of "clock," the premise of which is truly remarkable: Predict a person's age (or even lifespan), based on chemical modifications to their DNA that reflect the biological life history of the organism. Dr. Steve Horvath has analyzed large data sets of DNA methylation profiles to derive an algorithm that accurately predicts a person's chronological age across multiple cells, tissues, and organs, and even mammalian species. He built on this algorithm to develop second-generation clocks that could predict time-to-death among people of the same chronological age, as well as lifespan and healthspan. In this episode, Dr. Steven Horvath describes epigenetic clocks and their role in predicting – and possibly slowing – aging. Get this show's notes, timeline, and transcript: https://www.foundmyfitness.com/episodes/steve-horvath Dr. Horvath's faculty bio page: https://ph.ucla.edu/faculty/horvath Dr. Horvath's Wikipedia page: https://en.wikipedia.org/wiki/Steve_Horvath Dr. Rhonda Patrick's 3-minute video crash course in epigenetics: https://www.foundmyfitness.com/episodes/epigenetic-clock The FoundMyFitness overview article of epigenetic clocks: https://www.foundmyfitness.com/topics/epigenetic-clocks
About the podcast FoundMyFitness
A podcast about health, science, nutrition, aging, and fitness.