]Researchers are testing HIV drugs and monoclonal antibodies against long-lasting COVID-19, and what it takes to turn a symbiotic friend into an organelle   First up on the show this week, clinical trials of new and old treatments for Long Covid. Producer Meagan Cantwell is joined by Staff Writer Jennifer Couzin-Frankel and some of her sources to discuss the difficulties of studying and treating this debilitating disease.   People in this segment: ·      Michael Peluso ·      Sara Cherry ·      Shelley Hayden   Next: Move over mitochondria, a new organelle called the nitroplast is here. Host Sarah Crespi talks with Tyler Coale, a postdoctoral scholar in the University of California, Santa Cruz’s Ocean Sciences Department, about what exactly makes an organelle an organelle and why it would be nice to have inhouse nitrogen fixing in your cells.   This week’s episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Meagan Cantwell; Jennifer Couzin-Frankel   Episode page: https://www.science.org/doi/10.1126/science.zof5fvk Learn more about your ad choices. Visit megaphone.fm/adchoices

Tracing the arrival of rats using bones, isotopes, and a few shipwrecks; and what scientists have learned in 50 years about our famous ancestor Lucy   First on the show: Did rats come over with Christopher Columbus? It turns out, European colonists weren’t alone on their ships when they came to the Americas—they also brought black and brown rats to uninfested shores. Eric Guiry, a researcher in the Trent Environmental Archaeology Lab at Trent University, joins host Sarah Crespi to discuss how tiny slices of bone from early colony sites and sunken shipwrecks can tell us when these pesky rodents arrived.   Next, producer Meagan Cantwell talks with Contributing Correspondent Ann Gibbons about what has happened in the 50 years since anthropologists found Lucy—a likely human ancestor that lived 2.9 million to 3.3 million years ago. Although still likely part of our family tree, her place as a direct ancestor is in question. And over the years, her past has become less lonesome as it has become populated with other contemporaneous hominins.   This week’s episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Meagan Cantwell; Ann Gibbons LINKS FOR MP3 META   Episode page: https://www.science.org/doi/10.1126/science.z4scrgk   About the Science Podcast: https://www.science.org/content/page/about-science-podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

Robots that can smile in synchrony with people, and what ends up in the letters section First on this week’s show, a robot that can predict your smile. Hod Lipson, a roboticist and professor at Columbia University, joins host Sarah Crespi to discuss how mirrors can help robots learn to make facial expressions and eventually improve robot nonverbal communication.   Next, we have Margaret Handley, a professor in the department of epidemiology and biostatistics and medicine at the University of California San Francisco. She shares a letter she wrote to Science about how her past, her family, and a rare instrument relate to her current career focus on public health and homelessness. Letters Editor Jennifer Sills also weighs in with the kinds of letters people write into the magazine. Other Past as Prologue letters: A new frontier for mi familia by Raven Delfina Otero-Symphony A uranium miner’s daughter by Tanya J. Gallegos Embracing questions after my father’s murder by Jacquelyn J. Cragg A family’s pride in educated daughters by Qura Tul Ain One person’s trash: Another’s treasured education by Xiangkun Elvis Cao   This week’s episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Jennifer Sills   Episode page: https://www.science.org/doi/10.1126/science.zy9w2u0   About the Science Podcast: https://www.science.org/content/page/about-science-podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

New clinical trials for treatments of an always fatal brain disease, and what happens with pests when a conventional and organic farm are neighbors   First up on this week’s show, a new treatment to stave off prion disease goes into clinical trials. Prions are misfolded proteins that clump together and chew holes in the brain. The misfolding can be switched on in a number of ways—including infection with a misfolded prion protein from an animal or person. Staff Writer Meredith Wadman talks with host Sarah Crespi about new potential treatments—from antisense nucleotides to small molecules that interfere with protein production—for these fatal neurodegenerative diseases.   Next on the show: Freelance producer Katherine Irving talks with Ashley Larsen, associate professor of agricultural and landscape ecology at the University of California, Santa Barbara, about the effects of organic farms on their neighbors. If there are lots of organic growers together, pesticide use goes down but conventional farms tend to use more pesticides when side by side with organic farms.   This week’s episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Katherine Irving; Meredith Wadman LINKS FOR MP3 META   Episode page: https://www.science.org/doi/10.1126/science.z91m76v Learn more about your ad choices. Visit megaphone.fm/adchoices

Investigating “infantile amnesia,” and how generalized fear after acute stress reflects changes in the brain   This week we have two neuroscience stories. First up, freelance science journalist Sara Reardon looks at why infants’ memories fade. She joins host Sarah Crespi to discuss ongoing experiments that aim to determine when the forgetting stops and why it happens in the first place.   Next on the show, Hui-Quan Li, a senior scientist at Neurocrine Biosciences, talks with Sarah about how the brain encodes generalized fear, a symptom of some anxiety disorders such as social anxiety and post-traumatic stress disorder.   This week’s episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Kevin McLean; Sara Reardon   Episode page: https://www.science.org/doi/10.1126/science.z9bqkyc Learn more about your ad choices. Visit megaphone.fm/adchoices

What modern Indian genomes say about the region’s deep past, and how vitamin A influences stem cell plasticity First up this week, Online News Editor Michael Price and host Sarah Crespi talk about a large genome sequencing project in India that reveals past migrations in the region and a unique intermixing with Neanderthals in ancient times.   Next on the show, producer Kevin McLean chats with Matthew Tierney, a postdoctoral fellow at Rockefeller University, about how vitamin A and stem cells work together to grow hair and heal wounds.   This week’s episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Kevin McLean; Michael Price Episode page: https://www.science.org/doi/10.1126/science.zfhqarg   About the Science Podcast: https://www.science.org/content/page/about-science-podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

Keeping water out of the stratosphere could be a low-risk geoengineering approach, and using magnets to drive medical robots inside the body   First up this week, a new approach to slowing climate change: dehydrating the stratosphere. Staff Writer Paul Voosen joins host Sarah Crespi to discuss the risks and advantages of this geoengineering technique.   Next on the show, Science Robotics Editor Amos Matsiko gives a run-down of papers in a special series on magnetic robots in medicine. Matsiko and Crespi also discuss how close old science fiction books came to predicting modern medical robots’ abilities.   This week’s episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Paul Voosen; Amos Matsiko   Episode page: https://www.science.org/doi/10.1126/science.zvvddhw Learn more about your ad choices. Visit megaphone.fm/adchoices

On this week’s show: Factors that pushed snakes to evolve so many different habitats and lifestyles, and news from the AAAS annual meeting   First up on the show this week, news from this year’s annual meeting of AAAS (publisher of Science) in Denver. News intern Sean Cummings talks with Danielle Wood, director of the Space Enabled Research Group at the Massachusetts Institute of Technology, about the sustainable use of orbital space or how space exploration and research can benefit everyone.   And Newsletter Editor Christie Wilcox joins host Sarah Crespi with an extravaganza of meeting stories including a chat with some of the authors of this year’s Newcomb Cleveland Prize–winning Science paper on how horses spread across North America.   Voices in this segment:   William Taylor, assistant professor and curator of archaeology at the University of Colorado Boulder’s Museum of Natural History   Ludovic Orlando, director of the Centre for Anthropobiology and Genomics of Toulouse   University of Oklahoma archaeologists Sarah Trabert and Brandi Bethke   Yvette Running Horse Collin, post-doctoral researcher Paul Sabatier University (Toulouse III)     Next on the show: What makes snakes so special? Freelance producer Ariana Remmel talks with Daniel Rabosky, professor in ecology and evolutionary biology at the University of Michigan, about the drivers for all the different ways snakes have specialized—from spitting venom to sensing heat.   This week’s episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Ariana Remmel; Christie Wilcox; Sean Cummings   Episode page: https://www.science.org/doi/10.1126/science.zabhbwe Learn more about your ad choices. Visit megaphone.fm/adchoices

Why squeezing a blueberry doesn’t get you blue juice, and a myth buster and a science editor walk into a bar   First up on the show this week, MythBusters’s Adam Savage chats with Science Editor-in-Chief Holden Thorp about the state of scholarly publishing, better ways to communicate science, plus a few myths Savage still wants to tackle.   Next on the show, making blueberries without blue pigments. Rox Middleton, a postdoctoral fellow at the Dresden University of Technology and honorary research associate at the University of Bristol, joins host Sarah Crespi to talk about how blueberries and other blue fruits owe their hue to a trick of the light caused by specialized wax on their surface.   In a sponsored segment from the Science/AAAS Custom Publishing Office, Erika Berg, director and senior editor of custom publishing, interviews professor Jim Wells about organoid therapies. This segment is sponsored by Cincinnati Children’s Hospital.   This week’s episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Holden Thorp   Episode page: https://www.science.org/doi/10.1126/science.z7ye2st Learn more about your ad choices. Visit megaphone.fm/adchoices

More than 200 materials could be “altermagnets,” and the impact of odiferous pollutants on nocturnal plant-pollinator interactions   First up on the show this week, researchers investigate a new kind of magnetism. Freelance science journalist Zack Savitsky joins host Sarah Crespi to talk about recent evidence for “altermagnetism” in nature, which could enable new types of electronics.   Next on the show, producer Meagan Cantwell talks with Jeremy Chan, a postdoctoral researcher at the University of Naples Federico II, about how air pollution can interfere with pollinator activities—is the modern world too smelly for moths to do their work?   This week’s episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Meagan Cantwell; Zack Savitsky   Episode page: https://www.science.org/doi/10.1126/science.zz09cbu Learn more about your ad choices. Visit megaphone.fm/adchoices

A remote island may hold clues for the future of El Niño and La Niña under climate change, and how pressure in the blood sends messages to neurons   First up, researchers are digging into thousands of years of coral to chart El Niño’s behavior over time. Producer Kevin McLean talks with Staff Writer Paul Voosen about his travels to the Pacific island of Vanuatu to witness the arduous task of reef drilling.   Next on the show, host Sarah Crespi talks with Veronica Egger, a professor of neurophysiology at the Regensburg University Institute of Zoology, about an unexpected method of signaling inside the body. Egger’s work suggests the pulse of the blood—the mechanical drumming of it—affects neurons in the brain. The two discuss why this might be a useful way for the body to talk to itself.   This week’s episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Kevin McLean; Paul Voosen    Episode page: https://www.science.org/doi/10.1126/science.z1hqrn2 Learn more about your ad choices. Visit megaphone.fm/adchoices

On this week’s show: A roundup of stories from our daily newsletter, and the ripple effects of the invasive big-headed ant in Kenya First up on the show, Science Newsletter Editor Christie Wilcox joins host Sarah Crespi to talk about snake venom antidotes, a surprising job for a hangover enzyme, and crustaceans that spin silk. Next on the show, the cascading effects of an invading ant. Douglas Kamaru, a Ph.D. student in the Department of Zoology & Physiology at the University of Wyoming, discusses how the disruption of a mutually beneficial relationship between tiny ants and spiny trees in Kenya led to lions changing their hunting strategies. This week’s episode was produced with help from Podigy. About the Science Podcast Authors: Sarah Crespi; Christie Wilcox Episode page: https://www.science.org/doi/10.1126/science.zd5mbue Learn more about your ad choices. Visit megaphone.fm/adchoices

Investigation shows journal editors getting paid to publish bunk papers, and new techniques for finding tumor DNA in the blood   First up on this week’s episode, Frederik Joelving, an editor and reporter for the site Retraction Watch, talks with host Sarah Crespi about paper mills—organizations that sell authorship on research papers—that appear to be bribing journal editors to publish bogus articles. They talk about the drivers behind this activity and what publishers can do to stop it.   Next, producer Zakiya Whatley of the Dope Labs podcast talks with researcher Carmen Martin-Alonso, a graduate student in the Harvard–Massachusetts Institute of Technology Program in Health Sciences and Technology, about improving liquid biopsies for cancer. They discuss novel ways to detect tumor DNA circulating in the blood.   This week’s episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Zakiya Whatley; Richard Stone    Episode page: https://www.science.org/doi/10.1126/science.zahpt8h   About the Science Podcast: https://www.science.org/content/page/about-science-podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

Assessing environmental damage during wartime, and tracking signaling between fetus and mother   First up, freelance journalist Richard Stone returns with news from his latest trip to Ukraine. This week, he shares stories with host Sarah Crespi about environmental damage from the war, particularly the grave consequences of the Kakhovka Dam explosion.   Next, producer Kevin McLean talks with researcher Nardhy Gomez-Lopez, a professor in the department of obstetrics and gynecology and pathology and immunology in the Center for Reproductive Health Sciences at Washington University School of Medicine in St. Louis. The two discuss signaling between fetus and mother during childbirth and how understanding this crosstalk may one day help predict premature labor.   Finally, in a sponsored segment from the Science/AAAS Custom Publishing Office, Erika Berg, director and senior editor for the Custom Publishing Office, interviews Andrew Pospisilik, chair and professor of epigenetics at the Van Andel Institute, about his research into how epigenetics stabilizes particular gene expression patterns and how those patterns affect our risk for disease. This segment is sponsored by the Van Andel Institute.   This week’s episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Kevin McLean; Rich Stone   Episode page: https://www.science.org/doi/10.1126/science.z5jiifi Learn more about your ad choices. Visit megaphone.fm/adchoices

Best of online news, and screening for tuberculosis using sound   This week’s episode starts out with a look back at the top 10 online news stories with Online News Editor David Grimm. There will be cat expressions and mad scientists, but also electric cement and mind reading. Read all top 10 here.   Next on the show, can a machine distinguish a tuberculosis cough from other kinds of coughs? Manuja Sharma, who was a Ph.D. student in the department of electrical and computer engineering at the University of Washington at the time of the work, joins host Sarah Crespi to talk about her project collecting a cough data set to prove this kind of cough discrimination is possible with just a smartphone.   This week’s episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; David Grimm   Audio credit for human infant cries: Nicolas Grimault, Nicolas Mathevon, Florence Levréro; Neuroscience Research Center, ENES and CAP team. UJM, CNRS, France.   Episode page: https://www.science.org/doi/10.1126/science.zpuo5vn   About the Science Podcast: https://www.science.org/content/page/about-science-podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

Seeking the Majorana fermion particle, and a look at El Salvador’s adoption of cryptocurrency   First up on the show this week, freelance science journalist Zack Savitsky and host Sarah Crespi discuss the hunt for the elusive Majorana fermion particle, and why so many think it might be the best bet for a functional quantum computer. We also hear the mysterious tale of the disappearance of the particle’s namesake, Italian physicist Ettore Majorana.   Next in the episode, what happens when you make a cryptocurrency legal tender? Diana Van Patten, professor of economics in the Yale University School of Management, discusses the results of El Salvador’s adoption of bitcoin in 2021.   This week’s episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Zack Savitsky Episode page: https://www.science.org/doi/10.1126/science.zjvhsy8   About the Science Podcast: https://www.science.org/content/page/about-science-podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

Top science from 2023, and a genetic tool for pangolin conservation   First up this week, it’s Science’s Breakthrough of the Year with producer Meagan Cantwell and News Editor Greg Miller. But before they get to the tippy-top science find, a few of this year’s runners-up. See all our end-of-year coverage here.   Next, Jen Tinsman, a forensic wildlife biologist at the U.S. Fish and Wildlife Service, joins host Sarah Crespi to discuss using genetics to track the illegal pangolin trade. These scaly little guys are the most trafficked mammals in the world, and researchers can now use DNA from their scales to find poaching hot spots.   This week’s episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Meagan Cantwell; Greg Miller   Episode page: https://www.science.org/doi/10.1126/science.zk0pw91   About the Science Podcast: https://www.science.org/content/page/about-science-podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

A look at cognition in livestock, and the coevolution of wild bird–human cooperation   This week we have two stories on thinking and learning in animals. First, Online News Editor David Grimm talks with host Sarah Crespi about a reporting trip to the Research Institute for Farm Animal Biology in northern Germany, where scientists are studying cognition in farm animals, including goats, cows, and pigs. And because freelance audio producer Kevin Caners went along, we have lots of sound from the trip—so prepare yourself for moos and more.   Voices in this story: Christian Nawroth Annkatrin Pahl Jan Langbein   Next, audio producer Katherine Irving talks with Claire Spottiswoode, an evolutionary biologist at the University of Cambridge, about her research into cooperation between honeyguide birds and human honey hunters. In their Science study, Spottiswoode and her team found honeyguides learn distinct signals made by honey hunters from different cultures suggesting that cultural coevolution has occurred.   Read a related Perspective.   This week’s episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; David Grimm; Katherine Irving   Episode page: https://www.science.org/doi/10.1126/science.zr3zfn1 Learn more about your ad choices. Visit megaphone.fm/adchoices

Raising the pH of the ocean to reduce carbon in the air, and robots that can landscape   First up on this week’s show, Contributing Correspondent Warren Cornwall discusses research into making oceans more alkaline as a way to increase carbon capture and slow climate change. But there are a few open questions with this strategy: Could enough material be dumped in the ocean to slow climate change? Would mining that material release a lot of carbon? And, would either the mining or ocean changes have big impacts on ecosystems or human health?   Next, we hear from Ryan Luke Johns, a recent Ph.D. graduate from ETH Zürich, about why we want robots building big rocky structures from found materials: It reduces energy costs and waste associated with construction, and it would allow us to build things remotely on Mars.   This week’s episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Warren Cornwall   Episode page: https://www.science.org/doi/10.1126/science.z66mytn Learn more about your ad choices. Visit megaphone.fm/adchoices

A leap in supercomputing is a leap for science, cracking the dolomite problem, and a book on where patriarchy came from   First up on this week’s show, bigger supercomputers help make superscience. Staff Writer Robert F. Service joins host Sarah Crespi to discuss how the first exascale computer is enabling big leaps in scientists’ models of the world.   Next, producer Meagan Cantwell talks with the University of Michigan’s Wenhao Sun, professor of materials science and engineering, and graduate student Joonsoo Kim. They discuss solving the centuries-old problem of growing the common mineral dolomite in the lab.   Finally, books host Angela Saini is back but this time she’s in the hot seat talking about her own book, The Patriarchs: The Origins of Inequality. Science Books Editor Valerie Thompson and host Sarah Crespi chat with Angela about what history, archaeology, and biology reveal about where and when patriarchy started. See our whole series of books podcasts on sex, gender, and science.   This week’s episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Valerie Thompson; Angela Saini; Robert Service   Episode page: https://www.science.org/doi/10.1126/science.adn0660 Learn more about your ad choices. Visit megaphone.fm/adchoices