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by Rhonda Patrick, Ph.D.
The Aliquot Preview

PREVIEW Aliquot #6: Genetic and lifestyle risk factors for Alzheimer's disease


The single most important genetic risk factor for Alzheimer's disease is a variant of apolipoprotein E, or APOE for short, a lipoprotein produced in the liver and brain. Roughly a quarter of all people living in the US – about 75 million people – carry a genetic variant of APOE called APOE4. Having APOE4 is associated with higher circulating levels of LDL cholesterol and an increased risk for Alzheimer's disease.

But having APOE4 doesn't mean that Alzheimer's disease is inevitable. In fact, lifestyle behaviors can modulate risk for the disease, too, especially sleep, which provides an opportunity to rid the brain of toxic metabolic byproducts that can contribute to Alzheimer's disease risk. Understanding our genetic risks and addressing lifestyle behaviors – especially our sleep patterns – can influence whether a person eventually develops Alzheimer's disease.

These Aliquot segments feature Dr. Charles Raison, a professor of psychiatry, and Dr. Matthew Walker, a professor of neuroscience and psychology.

You can see the original full interview with Dr. Raison on YouTube:


FoundMyFitness episode page:


You can see the original full interview with Dr. Walker on YouTube:


FoundMyFitness episode page:




by Rhonda Patrick, Ph.D.